Cardiac Syndrome X: Definition, Clinical Context, and Cardiology Overview
Cardiac Syndrome X is a clinical condition where a person has angina-like chest pain and evidence suggesting ischemia, but coronary angiography does not show obstructive coronary artery disease. It belongs to the category of ischemic heart disease syndromes, often discussed under “microvascular angina” and related concepts. It is commonly encountered when evaluating chest pain, abnormal stress testing, or persistent symptoms despite “normal” epicardial coronary arteries. It is distinct from “metabolic syndrome X,” which refers to insulin resistance and cardiometabolic risk factors.